Volume 30, No 8, Aug 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 8, August 2020: 633-634

RESEARCH HIGHLIGHTS

Reprogramming the microenvironment: tricks of tumor-derived astrocytes

Guoxin Zhang , Jeremy N. Rich^*

Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA 92037, USA
Correspondence: Jeremy N. Rich(drjeremyrich@gmail.com)

Medulloblastomas generate a complex ecosystem through the simultaneous evolution of tumor progenitor cells and transdifferentiated progeny (tumor-derived astrocytes). In a recent Cell paper, Yao et al. show that tumor-derived astrocytes secrete interleukin-4 to reprogram the innate immune system by polarizing resident brain microglia towards pro-tumorigenic tumor-associated macrophages that secrete insulin-like growth factor 1, feeding back to stimulate tumor progenitor proliferation.

https://doi.org/10.1038/s41422-020-0335-4

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