Volume 30, No 9, Sep 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 9, September 2020: 711-712

RESEARCH HIGHLIGHTS

Making ends meet in class switch recombination

Lizhen Wu , David G. Schatz^*

Department of immunobiology, Yale School of Medicine, New Haven, CT 06519, USA
Correspondence: David G. Schatz(david.schatz@yale.edu)

Liu et al. revealed that ERCC6L2 is a DNA double strand break repair factor that both enhances the efficiency of immunoglobulin gene class switch recombination and dictates the proper orientation of end joining. ERCC6L2 rapidly localizes to DNA breaks and is necessary for efficient recruitment of other repair factors, suggesting an integral and early role in the complex process that allows for the expression of antibodies with different effector functions.

https://doi.org/10.1038/s41422-020-0342-5

FULL TEXT | PDF

Browse 1320