Volume 30, No 8, Aug 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 8, August 2020: 637-638

RESEARCH HIGHLIGHTS

Combating pancreatic cancer during its Rip Van Winkle sleep

Kıvanç Görgülü , Marina Lesina , Hana Algül^*

Comprehensive Cancer Center Munich at the Klinikum rechts der Isar (CCCMTUM), Technische Universität München, 81675 Munich, Germany
Correspondence: Hana Algül(hana.alguel@mri.tum.de)

In a recent paper published in Cell , Ruscetti et al. showed that therapy-induced senescence in pancreatic ductal adenocarcinoma (PDAC) rewires vascular network within the cancer, which in turn makes tumor susceptible to chemotherapy. Moreover, senescence-associated secretory phenotype-dependent activation of cancer vasculature increases T cell invasion into PDAC structures, thereby allowing better outcome of immunotherapy.

https://doi.org/10.1038/s41422-020-0348-z

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