Volume 30, No 8, Aug 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 8, August 2020: 631-632

RESEARCH HIGHLIGHTS

GABAB receptor pas de deux: insights from high-resolution structures

Yi Jiang^1,2,* , H. Eric Xu^1,2,3,*

¹The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203 Shanghai, China
²University of Chinese Academy of Sciences, 100049 Beijing, China
³School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China
Correspondence: Yi Jiang(yijiang@simm.ac.cn)H. Eric Xu(eric.xu@simm.ac.cn)

The GABA B receptors are heterodimeric class C G protein-coupled receptors (GPCRs) that mediate the inhibitory neurotransmission in the central nervous system and they are drug targets for alcoholism and pain control. In a recent paper published in Cell Research, Mao et al. reported the first full-length GABA B heterodimer structures in both inactive and active states, providing a framework for understanding the activation of class C GPCRs and a template for designing allosteric modulators targeting the dimeric interface of the GABA B receptors.

https://doi.org/10.1038/s41422-020-0373-y

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