Volume 30, No 11, Nov 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 11, November 2020: 944-945

RESEARCH HIGHLIGHTS

Twin peaks: finding fragile sites with MiDAS-seq

Thomas W. Glover^1,2,* , Thomas E. Wilson^1,2

¹Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
²Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Correspondence: Thomas W. Glover(glover@med.umich.edu)

Two papers from Macheret et al. and Ji et al. describe novel high-resolution direct sequencing approaches to map fragile sites and hundreds of additional genomic regions that can remain under-replicated prior to mitotic entry and complete replication in mitosis. They further establish many defining properties of these loci that greatly add to our mechanistic understanding of fragile sites and genome instability following replication stress.

https://doi.org/10.1038/s41422-020-0376-8

FULL TEXT | PDF

Browse 922