Volume 31, No 2, Feb 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 2, February 2021: 233-236

LETTERS TO THE EDITOR

Mitochondrial replacement in macaque monkey offspring by first polar body transfer

Zhanyang Wang¹ , Yuzhuo Li² , Xianfa Yang³ , Yan Wang¹ , Yanhong Nie¹ , Yuting Xu¹ , Xiaotong Zhang¹ , Yong Lu¹ , Tikui Zhang¹ , Qiming Liu¹ , Naihe Jing³ , Zhen Liu^1,* , Qiang Sun^1,*

¹Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
²Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
³Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China
Correspondence: Zhen Liu(zliu2010@ion.ac.cn)Qiang Sun(qsun@ion.ac.cn)

Dear Editor,

Mitochondrial DNA (mtDNA) mutations are maternally inherited to the offspring and mitochondrial replacement therapy (MRT) provides a promising approach for preventing mtDNA-related diseases.1,2 First polar body transfer (PB1T) has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.3,4 However, generation of primate offspring using PB1T has not been reported. Here, we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey (Macaca fascicularis), a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT.

https://doi.org/10.1038/s41422-020-0381-y

FULL TEXT | PDF

Browse 1111