Volume 30, No 9, Sep 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 9, September 2020: 713-714

RESEARCH HIGHLIGHTS

Unconventional secretion: cargo channeling by TMED10

Tan A. Nguyen , Jayanta Debnath^*

Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94010, USA
Correspondence: Jayanta Debnath(jayanta.debnath@ucsf.edu)

Cytosolic proteins lacking a signal peptide are often loaded into vesicles and secreted via unconventional protein secretion pathways. A recent paper in Cell identifies the transmembrane protein TMED10 as a protein channel for the vesicular translocation and secretion of mature IL-1β and other leaderless cargoes.

https://doi.org/10.1038/s41422-020-0382-x

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