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Volume 30, No 10, Oct 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 10, October 2020: 936-939   |  Open Access

LETTERS TO THE EDITOR

A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice

Jing Lu1 , Guoliang Lu1 , Shudan Tan1 , Jia Xia2 , Hualong Xiong3 , Xiaofei Yu4 , Qingqing Qi4 , Xiang Yu5 , Li Li1 , Hang Yu6 , Ningshao Xia3 , Tianying Zhang3,* , Yingjie Xu5,* , Jinzhong Lin1,*

1State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China
2Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
3State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, Fujian 361102, China
4State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China
5Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
6Shanghai RNACure Biopharma Co., Ltd, Shanghai 200438, China
These authors contributed equally: Jing Lu, Guoliang Lu, Shudan Tan, Jia Xia, Hualong Xiong, Xiaofei Yu Correspondence: Tianying Zhang(tyzhang1003@163.com)Yingjie Xu(xuyingjie@shsmu.edu.cn)Jinzhong Lin(linjinzhong@fudan.edu.cn)

Dear Editor,

Since the beginning of this century, humanity has been struck three times by the coronavirus outbreak. The most recent one is caused by the SARS-CoV-2 virus, which was first reported in January 2020 and spread rapidly worldwide, developing into a global coronavirus disease pandemic coded COVID-19.1 By July 28, 2020, SARS-CoV-2 has caused over sixteen million COVID-19 cases worldwide and 650,805 deaths.2 Such a grave situation has made the development of a COVID-19 vaccine imperative and urgent.3



https://doi.org/10.1038/s41422-020-00392-7

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