Volume 30, No 10, Oct 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 10, October 2020: 831-832

RESEARCH HIGHLIGHTS

IL-18: throwing off the shackles to boost anti-tumor immunity

Karen O. Dixon , Vijay K. Kuchroo^*

Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Correspondence: Vijay K. Kuchroo(vkuchroo@evergrande.hms.harvard.edu)

In a new study in Nature , Zhou et al. identify IL-18BP as a novel soluble immune checkpoint, and describe engineering of a decoy-resistant IL-18 to overcome this barrier and drive potent anti-tumor immunity.

https://doi.org/10.1038/s41422-020-00396-3

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