Volume 31, No 2, Feb 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 2, February 2021: 105-106

RESEARCH HIGHLIGHT

An exosome pathway without an ESCRT

Candia M. Kenific¹ , Haiying Zhang^,* , David Lyden^,*

¹Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, US
Correspondence: Haiying Zhang(haz2005@med.cornell.edu)David Lyden(dcl2001@med.cornell.edu)

Exosome biogenesis occurs via multiple mechanisms, but how these pathways are controlled remains poorly understood. In a recent study published in Cell Research, Wei et al. identify Rab31 GTPase as a regulator of lipid-mediated exosome biogenesis independent of other commonly-recognized ESCRT and tetraspanin pathways.

https://doi.org/10.1038/s41422-020-00418-0

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