Volume 31, No 2, Feb 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 2, February 2021: 237-240   |  Open Access

LETTERS TO THE EDITOR

Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

Mingli Zhu^1,2 , Qin Zou^2,3 , Rongyao Huang^2,3 , Ying Li¹ , Xudong Xing^2,3 , Jianhuo Fang^2,3 , Liang Ma¹ , Lifei Li^2,3 , Xuerui Yang^3,* , Li Yu^1,*

¹State Key Laboratory of Membrane Biology, Tsinghua UniversityPeking University Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Science, Tsinghua University, Beijing 100084, China
²Joint Graduate Program of Peking-Tsinghua-National Institute of Biological Science, Tsinghua University, Beijing 100084, China
³MOE Key Laboratory of Bioinformatics, Tsinghua University, Center for Synthetic & Systems Biology, Tsinghua University, School of Life Science, Beijing 100084, China
These authors contributed equally: Mingli Zhu, Qin Zou Correspondence: Xuerui Yang(yangxuerui@tsinghua.edu.cn)Li Yu(liyulab@tsinghua.edu.cn)

Dear Editor,

Migrasomes are recently discovered vesicular organelles which form on the retraction fibers (RFs) of migrating cells.1 Once detached from cells, migrasomes can rupture and release their luminal contents1 in a process named migracytosis. Recently, migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo.2 Thus, migracytosis is considered as a major mechanism for migrasomes to carry out their functions. It has been frequently observed that intact migrasomes can be engulfed by surrounding cells,1 and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells. However, it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells.

https://doi.org/10.1038/s41422-020-00415-3

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