Volume 30, No 12, Dec 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 12, December 2020: 1055-1056

RESEARCH HIGHLIGHTS

Keeping innate immune response in check: when cGAS meets the nucleosome

Wei Xie^* , Dinshaw J. Patel^*

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Correspondence: Wei Xie(xiew@mskcc.org)Dinshaw J. Patel(pateld@mskcc.org)

Cao et al. report on cryo-EM structures of human cyclic GMP-AMP synthase (cGAS) sensor bound to the nucleosome core particle, thereby defining the molecular mechanism of how cGAS avoids activation by chromatinized self-DNA. Notably, disruption of cGAS dimer formation and prevention of dsDNA recognition by the sensor at the nucleosome level impede cGAS activation.

https://doi.org/10.1038/s41422-020-00423-3

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