Volume 30, No 11, Nov 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 11, November 2020: 948-949

RESEARCH HIGHLIGHTS

CAR T cells: from tinkering to rational design

Bernard Malissen^1,2,*

¹Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France
²Centre d’Immunophénomique, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France
Correspondence: Bernard Malissen(bernardm@ciml.univ-mrs.fr)

Hartl et al. and Wu et al. revealed that the CD3ε subunit of the TCR–CD3 complex — a central player of T cell activation — contains previously unrecognized signaling motifs that permit its functional coupling to tyrosine protein kinases. When grafted into chimeric antigen receptors (CARs), such signaling motifs enhance the antitumor activity of CAR T cells, a promising class of anti-tumoral therapeutics.

https://doi.org/10.1038/s41422-020-00420-6

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