Volume 30, No 12, Dec 2020

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 30 Issue 12, December 2020: 1057-1058

RESEARCH HIGHLIGHTS

Resident macrophages keep mitochondria running in the heart

Ronald J. Vagnozzi^1,2,* , Jeffery D. Molkentin^1,3,*

¹Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
²Division of Cardiology, Department of Medicine, Consortium for Fibrosis Research & Translation, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
³Howard Hughes Medical Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Correspondence: Ronald J. Vagnozzi(ronald.vagnozzi@cuanschutz.edu)Jeffery D. Molkentin(jeff.molkentin@cchmc.org)

The high workload of cardiac myocytes, coupled with their negligible turnover, requires that compensatory mechanisms act in the heart to address ongoing cellular damage and extruded organelle components that would otherwise accumulate. A recent study in Cell by Nicolás-Ávila et al. illustrates how cardiac-resident macrophages serve such a role, by clearing extruded mitochondrial debris to preserve organ homeostasis and maintain optimal cardiac function.

https://doi.org/10.1038/s41422-020-00427-z

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