Volume 31, No 4, Apr 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 4, April 2021: 379-380

RESEARCH HIGHLIGHTS

TDP-43 triggers immune response via mitochondrial DNA release

Sunny Kumar , Jean-Pierre Julien^*

Department of Psychiatry and Neuroscience, University Laval, CERVO Brain Research Centre, 2601 de la Canardière, Québec City, QC G1J 2G3, Canada
Correspondence: Jean-Pierre Julien(jean-pierre.julien@fmed.ulaval.ca)

The molecular mechanisms of toxicity associated with cytoplasmic accumulation of TAR DNA binding protein-43 (TDP-43), a pathological feature of many neurodegenerative diseases, are not fully understood. A recent study by Yu et al. is proposing that noxious neuroinflammatory stimulation associated with TDP-43 pathology is caused by excess TDP-43 penetration into mitochondria followed by cytosolic release of mitochondrial DNA (mtDNA) and activation of the cGAS/STING immune sensor.

https://doi.org/10.1038/s41422-020-00461-x

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