Volume 31, No 4, Apr 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 4, April 2021: 377-378

RESEARCH HIGHLIGHTS

Young haematopoietic stem cells are picky eaters

Nick van Gastel^1,2 , David T. Scadden^1,3,*

¹Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
²de Duve Institute, Brussels, Belgium
³Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02138, USA
Correspondence: David T. Scadden(david_scadden@harvard.edu)

In a recent study published in Nature, Dong et al. describe how haematopoietic stem cells (HSCs) rely on chaperone-mediated autophagy (CMA), a form of highly selective lysosomal protein degradation, as a metabolic quality control mechanism. While old HSCs have reduced CMA activity, re-activation of CMA can boost their functionality, providing exciting therapeutic perspectives.

https://doi.org/10.1038/s41422-021-00488-8

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