Volume 31, No 7, Jul 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 7, July 2021: 727-729

RESEARCH HIGHLIGHTS

Remote light-activation of native Orai channels

Sarah A. Kazzaz , James H. Baraniak Jr , Yandong Zhou , Donald L. Gill^*

Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Correspondence: Donald L. Gill(dongill@psu.edu)

Optogenetic control of the Ca 2+ signaling machinery has been a powerful approach but requires complex cell manipulation to introduce modified genes. A newly developed non-invasive, ultrafast laser technique allows for the remote activation of native Orai1 Ca 2+ channels, without the need for gene introduction, protein expression, or exogenous reagents.

https://doi.org/10.1038/s41422-021-00484-y

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