Volume 31, No 8, Aug 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 8, August 2021: 834-835

RESEARCH HIGHLIGHTS

Pancreatic endocrinogenesis revisited: “I have all the answers, who has the questions?”

Willem Staels^1,* , Raphael Scharfmann^2,*

¹The Beta Cell Neogenesis (BENE) Research Group, Vrije Universiteit Brussel (VUB) and the Service of Pediatric Endocrinology, Department of Pediatrics, KidZ Health Castle, Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium
²Université de Paris, Institut Cochin, INSERM, U1016 Paris, France
Correspondence: Willem Staels(willem.staels@vub.be)Raphael Scharfmann(raphael.scharfmann@inserm.fr)

The endocrine pancreas is composed of islets of Langerhans that are scattered throughout the gland and contain multiple hormone-producing cell types (α, β, δ, PP and ε cells); endocrine progenitors (EPs) can differentiate into these distinct lineages, but the regulation of their fate choice — especially for the low-abundance δ, PP and ε cells — remains incompletely understood. In a paper published in Cell Research , Yu et al. provide a notable resource to decipher the differentiation pathways of murine and human EPs.

https://doi.org/10.1038/s41422-021-00489-7

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