Volume 31, No 7, Jul 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 7, July 2021: 730-731

RESEARCH HIGHLIGHTS

Self-made allostery: endogenous COMP antagonizes pathologic AT1AR signaling

Ama Dedo Okyere , Douglas G. Tilley^*

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA
Correspondence: Douglas G. Tilley(douglas.tilley@temple.edu)

The identification and development of biased modulators of proximal G protein-coupled receptor (GPCR) signaling to prevent pathological disease progression has been at the forefront of recent drug discovery efforts. Recently, Fu et al. identified cartilage oligomeric matrix protein (COMP) as an endogenous negative allosteric modulator of β-arrestin (βarr)-dependent angiotensin II (Ang II) Type 1A receptor (AT1 A R) signaling, which attenuates the development of abdominal aortic aneurysm (AAA), a chronic inflammatory vascular disease lacking pharmacological treatment options.

https://doi.org/10.1038/s41422-021-00493-x

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