Volume 31, No 7, Jul 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 7, July 2021: 723-724

RESEARCH HIGHLIGHTS

Intestinal tête-à-tête: helminths blunt immunity against flaviviruses

David E. Place , Thirumala-Devi Kanneganti^*

Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Correspondence: Thirumala-Devi Kanneganti(Thirumala-Devi.Kanneganti@StJude.org)

Intestinal helminth infections are known to alter host immune responses, but their impact on neurotropic flaviviruses is poorly understood. A recent study in Cell by Desai et al. finds that helminth infection promotes a tuft cell immune response, via IL-4, that increases susceptibility to subsequent challenge by the mosquito-transmitted flavivirus, West Nile virus.

https://doi.org/10.1038/s41422-021-00505-w

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