Volume 31, No 7, Jul 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 7, July 2021: 725-726

RESEARCH HIGHLIGHTS

Ultrasensitive antigen density discrimination by synNotch

Divanshu Shukla , James L. Riley^*

Department of Microbiology, Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA
Correspondence: James L. Riley(rileyj@upenn.edu)

In a recent study published in Science , Hernandez-Lopez et al. engineered a low-to-high two-step regulatory circuit that allows T cells to discriminate target antigens with an ultrasensitive threshold. In this circuit, low-affinity synNotch receptor controls the expression of the high-affinity chimeric antigen receptor (CAR); thus, the only time the CAR construct is expressed is in the presence of high levels of antigen, preventing off-tumor CAR T cell recognition.

https://doi.org/10.1038/s41422-021-00511-y

FULL TEXT | PDF

Browse 725