Volume 31, No 8, Aug 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 8, August 2021: 827-828

RESEARCH HIGHLIGHTS

SARS-CoV-2 vaccines: anamnestic response in previously infected recipients

Jyothi N. Purushotham^1,2 , Neeltje van Doremalen¹ , Vincent J. Munster^1,*

¹Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
²The Jenner Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Correspondence: Vincent J. Munster(vincent.munster@nih.gov)

The continued evolution of SARS-CoV-2 has raised questions regarding the ability of prior immunity to early pandemic strains to afford protection against emerging variants. In a recent study, Stamatatos et al. demonstrate that currently approved mRNA vaccines elicit antibodies capable of neutralizing heterologous antigen and they further show that single-dose vaccination triggers an anamnestic response in individuals with pre-existing anti-RBD IgG developed through previous SARS-CoV-2 infection.

https://doi.org/10.1038/s41422-021-00516-7

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