Volume 31, No 11, Nov 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 11, November 2021: 1218-1221   |  Open Access

LETTERS TO THE EDITOR

Nuclear translocation of the 4-pass transmembrane protein Tspan8

Yuwei Huang¹ , Junjian Li² , Wanqing Du¹ , Siyang Li¹ , Ying Li¹ , Haozhi Qu¹ , Jingxuan Xv² , Li Yu¹ , Rongxuan Zhu² , Hongxia Wang^2,*

¹State Key Laboratory of Membrane Biology, Tsinghua-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
²State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence: Hongxia Wang(whx365@126.com)

Dear Editor,

Transmembrane proteins with multiple transmembrane domains are rarely found inside nuclei for good reason. To achieve intranuclear localization, the hypothetical transmembrane protein must first be extracted from its host membrane and the multiple hydrophobic transmembrane domains must be protected from the hydrophilic environment of the cytoplasm to maintain the proper conformation of the protein. Mechanistically, this poses considerable challenges.

https://doi.org/10.1038/s41422-021-00522-9

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