Volume 31, No 9, Sep 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 9, September 2021: 947-948

RESEARCH HIGHLIGHTS

Heart defects recapitulated in human cardioids

Valeria V. Orlova , Christine L. Mummery^*

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands
Correspondence: Christine L. Mummery(c.l.mummery@lumc.nl)

A major obstacle to understanding how and why congenital defects occur in the heart is the absence of models that recapitulate the basic cell lineage architecture of human heart development. In a recent study in Cell , Hofbauer and colleagues present compelling evidence that they have created such a model from human pluripotent stem cells by guiding self-organization within cell aggregates (or organoids) which they refer to as “cardioids”; these undergo patterning and morphogenesis to form a cavity-like chamber as in early heart development.

https://doi.org/10.1038/s41422-021-00534-5

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