Volume 31, No 9, Sep 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 9, September 2021: 949-950

RESEARCH HIGHLIGHTS

Somatic mutation accumulation seen through a single-molecule lens

Lovelace J. Luquette , Peter J. Park^*

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
Correspondence: Peter J. Park(peter_park@hms.harvard.edu)

Somatic mutations (SMs) accumulate over the lifetime of cells and can lead to cancer and other diseases; however, SMs can be difficult to detect, especially when they are present in very few cells. In a recent Nature paper, Abascal et al. develop a protocol capable of detecting SMs present on only a single molecule of DNA and apply it to both mitotic and post-mitotic human tissues.

https://doi.org/10.1038/s41422-021-00537-2

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