Volume 31, No 10, Oct 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 10, October 2021: 1123-1125   |  Open Access

LETTERS TO THE EDITOR

O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule

Wenmin Tian^1,2,† , Delin Li^3,† , Nan Zhang^1,2,† , Guijie Bai^3,4,† , Kai Yuan^3,4,† , Haixia Xiao³ , Feng Gao^3,* , Yang Chen^1,2,* , Catherine C. L. Wong^1,2,5,6,7,* , George Fu Gao^8,9,*

¹Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, Beijing, China
²School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
³Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China
⁴Shanxi Academy of Advanced Research and Innovation, Taiyuan, Shanxi, China
⁵PekingTsinghua Center for Life Sciences, Beijing, China
⁶Peking University First Hospital, Beijing, China
⁷Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
⁸CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
⁹National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
^†These authors contributed equally: Wenmin Tian, Delin Li, Nan Zhang, Guijie Bai and Kai Yuan. ✉
Correspondence: Feng Gao(gaofeng@tib. cas.cn)Yang Chen(chenyang1816185048@bjmu.edu.cn)Catherine C. L. Wong(catherine_wong@bjmu.edu.cn)George Fu Gao(gaof@im.ac.cn)

Dear Editor,

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), emerged in late 2019 and has since caused a pandemic. Although there have been extensive studies worldwide, our understanding of this newly emerged pathogen is far from sufficient. The pathogenesis of the SARS-CoV-2 infection is not fully understood, although a “two-stage” hypothesis was proposed in our previous study.1

https://doi.org/10.1038/s41422-021-00545-2

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