Volume 31, No 10, Oct 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 10, October 2021: 1043-1044

RESEARCH HIGHLIGHTS

Gasdermin B in the host–pathogen tug-of-war

Timurs Maculins^1,* , Ivan Dikic^2,*

¹Department of Cancer Immunology, Genentech, South San Francisco, CA, USA
²Institute of Biochemistry II, Goethe University, Frankfurt am Main, Germany
Correspondence: Timurs Maculins(maculins.timurs@gene.com)Ivan Dikic(dikic@biochem2.uni-frankfurt.de)

The Shigella flexneri effector IpaH7.8 targets gasdermin B for degradation in infected host cells. This bacterial strategy counteracts a host defense mechanism in which the lymphoid cell compartment activates the bactericidal properties of gasdermin B.

https://doi.org/10.1038/s41422-021-00544-3

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