Volume 31, No 11, Nov 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 11, November 2021: 1215-1217

LETTERS TO THE EDITOR

Time of day influences immune response to an inactivated vaccine against SARS-CoV-2

Hui Zhang^1,† , Yihao Liu^1,† , Dayue Liu^1,† , Qin Zeng^1,† , Liubing Li^1,† , Qian Zhou^1,† , Mengyuan Li^1,† , Jie Mei¹ , Niansheng Yang¹ , Suilin Mo¹ , Qiusheng Liu¹ , Min Liu¹ , Sui Peng^1,† , Haipeng Xiao^1,†,*

¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
^†These authors contributed equally: Hui Zhang, Yihao Liu, Dayue Liu, Qin Zeng, Liubing Li, Qian Zhou, Mengyuan Li, Sui Peng, Haipeng Xiao
Correspondence: Haipeng Xiao(xiaohp@mail.sysu.edu.cn)

Dear Editor,

The coronavirus disease 2019 (COVID-19) pandemic that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people and is an ongoing issue globally. The application of effective and safe vaccines is critical to achieving control of the pandemic.1 Data from clinical trials have shown that several vaccines can induce humoral and cellular immune responses against SARS-CoV-2.2,3,4 However, given the long time required for vaccine production, difficulty in vaccine distribution and public skepticism about their safety and benefits, the vaccine coverage rate is growing slowly worldwide. Therefore, to make full use of available resources and maximize the efficacy of vaccination is critically important in fighting against COVID-19.

https://doi.org/10.1038/s41422-021-00541-6

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