Volume 31, No 9, Sep 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 9, September 2021: 945-946

RESEARCH HIGHLIGHTS

Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets

Elena De Vita , Daniel Lucy , Edward W. Tate^*

Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK
Correspondence: Edward W. Tate(e.tate@imperial.ac.uk)

AuTophagy-TEthering Compounds (ATTECs) are a novel class of bifunctional molecules proposed to hijack the autophagosomal pathway for the degradation of potentially any cellular components in addition to proteins. Targeting stored fats in cells with LD·ATTECs suggests a novel approach to combating diseases implicating accumulation of lipid droplets, such as obesity, cardiovascular diseases, or cancer.

https://doi.org/10.1038/s41422-021-00546-1

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