Volume 31, No 10, Oct 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 10, October 2021: 1045-1046

RESEARCH HIGHLIGHTS

Linear ubiquitin chains break blood vessel branches

Yuri Shibata^* , David Komande^*

Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052 Melbourne, Australia
Correspondence: Yuri Shibata(shibata.y@wehi.edu.au)David Komande(dk@wehi.edu.au)

New work published in Molecular Cell by Fu et al. reveals that the protein kinase ALK1 is deregulated when the enzymes assembling and disassembling Met1-ubiquitination, LUBAC and OTULIN, are inhibited or missing. This latest non-degradative role for ubiquitin impacts on Smad1/5 signaling and deregulates angiogenesis downstream of bone morphogenetic proteins, adding to the growing list of Met1-polyubiquitin-regulated cellular pathways.

https://doi.org/10.1038/s41422-021-00553-2

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