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Submit Manuscript Volume 31, No 11, Nov 2021
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 31 Issue 11, November 2021: 1142-1143
ERASE: a novel nucleic-acid based antiviral mechanism
George Fu Gao1,2,*
1CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaNucleic acid-based antiviral systems, including CRISPR/Cas and RNA interference, play important roles in antiviral defense. In a paper recently published in Cell Research, Wu et al. revealed a novel nucleic acid-based antiviral mechanism against RNA viruses in mouse embryonic stem cells, which relies on the endogenous reverse transcriptase to produce viral complementary DNA and then RNase H1 to destroy the viral RNA.
https://doi.org/10.1038/s41422-021-00568-9