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Volume 31, No 11, Nov 2021

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 31 Issue 11, November 2021: 1142-1143

RESEARCH HIGHLIGHTS

ERASE: a novel nucleic-acid based antiviral mechanism

George Fu Gao1,2,*

1CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
2Chinese Center for Disease Control and Prevention, Beijing, China
Correspondence: George Fu Gao(gaof@im.ac.cn)

Nucleic acid-based antiviral systems, including CRISPR/Cas and RNA interference, play important roles in antiviral defense. In a paper recently published in Cell Research, Wu et al. revealed a novel nucleic acid-based antiviral mechanism against RNA viruses in mouse embryonic stem cells, which relies on the endogenous reverse transcriptase to produce viral complementary DNA and then RNase H1 to destroy the viral RNA.


https://doi.org/10.1038/s41422-021-00568-9

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