Volume 32, No 2, Feb 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 2, February 2022: 111-112

RESEARCH HIGHLIGHTS

TMED9–SEC12, an important “contact” for autophagy

Claudia Puri^1,2 , David C. Rubinsztein^1,2,*

¹Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
²UK Dementia Research Institute, University of Cambridge, Cambridge, UK
Correspondence: David C. Rubinsztein(dcr1000@cam.ac.uk)

Autophagosome biogenesis occurs via a complex mechanism that involves membranes from different subcellular compartments. Here, we review an elegant study from Li et al. describing a new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 that leads to the formation of COPII-coated vesicles essential for the formation of the autophagosome, and attempt to reconcile their findings with our studies proposing that the recycling endosome is a core platform for autophagosome biogenesis.

https://doi.org/10.1038/s41422-021-00579-6

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