Volume 32, No 2, Feb 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 2, February 2022: 113-114

RESEARCH HIGHLIGHTS

It’s just a phase: NLRP6 phase separations drive signaling

Rebecca E. Tweedell , Thirumala-Devi Kanneganti^*

Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Correspondence: Thirumala-Devi Kanneganti(Thirumala-Devi.Kanneganti@StJude.org)

NLRP6 is a key innate immune sensor whose functions have remained understudied. In a recent Cell paper, Shen et al. evaluate the mechanism of NLRP6 activation and find that double-stranded RNA interacts with NLRP6 and leads to liquid–liquid phase separation that is critical for NLRP6-dependent innate immune signaling.

https://doi.org/10.1038/s41422-021-00594-7

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