Volume 32, No 3, Mar 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 3, March 2022: 225-226

RESEARCH HIGHLIGHTS

The hens guarding epithelial cancer fox-houses

Liam T. Gaynor^1,2 , Ramesh A. Shivdasani^1,3,4,*

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
²Graduate Program in Biological & Biomedical Sciences, Harvard Medical School, Boston, MA, USA
³Department of Medicine, Harvard Medical School, Boston, MA, USA
⁴Harvard Stem Cell Institute, Cambridge, MA, USA
Correspondence: Ramesh A. Shivdasani(Ramesh_Shivdasani@dfci.harvard.edu)

Esophageal micro-tumors that form rapidly in a carcinogen-induced mouse model regress almost as fast. Normal-appearing Notch1-mutant clones with their own intrinsic cancer potential competitively extrude these micro-tumors from the epithelium, demonstrating their surprising short-term protection of the organism.

https://doi.org/10.1038/s41422-021-00599-2

FULL TEXT | PDF

Browse 463