Volume 32, No 3, Mar 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 3, March 2022: 229-230

RESEARCH HIGHLIGHTS

Muscularis macrophages: trained guardians of enteric neurons

Maria Francesca Viola , Guy Boeckxstaens^*

Center of Intestinal Neuro-Immune Interaction, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 3000 Leuven, Belgium
Correspondence: Guy Boeckxstaens(guy.boeckxstaens@kuleuven.be)

An intestinal helminth infection induces a tolerogenic phenotype of resident muscularis macrophages protecting the enteric nervous system against subsequent bacterial infections, an effect mediated by eosinophil-derived IL-4 and IL-13. This work further identifies muscularis macrophages as important players protecting the enteric nervous system against harmful events.

https://doi.org/10.1038/s41422-021-00602-w

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