Volume 32, No 1, Jan 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 1, January 2022: 3-4

RESEARCH HIGHLIGHTS

UHRF1: a novel metabolic guardian restricting AMPK activity

Che-Chia Hsu^1,† , Yau-Sheng Tsai^1,† , Hui-Kuan Lin^1,*

¹Department of Cancer Biology, Wake Forest Baptist Medical Center, Wake Forest University, Winston-Salem, NC, USA
^†These authors contributed equally: Che-Chia Hsu, Yau-Sheng Tsai
Correspondence: Hui-Kuan Lin(hulin@wakehealth.edu)

AMP-activated protein kinase (AMPK) serves as a central guardian maintaining energy homeostasis under nutrient stress and/or energy crisis. The study by Xu et al. identified that a nuclear factor UHRF1 (ubiquitin-like with plant homeodomain and RING finger domains 1) suppresses AMPK activity in the nucleus by recruiting PP2A to dephosphorylate AMPK at T172, which in turn governs cytoplasmic AMPK activity in regulation of glucose and lipid metabolism.

https://doi.org/10.1038/s41422-021-00589-4

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