Volume 32, No 3, Mar 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 3, March 2022: 227-228

RESEARCH HIGHLIGHTS

How to dodge pyroptosis: lessons from Shigella flexneri

Filip Van Hauwermeiren¹ , Mohamed Lamkanf^2,*

¹Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium
²Laboratory of Medical Immunology, Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium
Correspondence: Mohamed Lamkanf(mohamed.lamkanfi@ugent.be)

Bacillary dysentery is an intestinal infection caused by Shigella, a group of Gram-negative bacteria that roam freely in the cytosol of infected host cells. A recent publication by Li et al. in Nature shows that Shigella flexneri actively targets caspase-4/11 via a novel posttranslational modification to dodge pyroptosis induction by the noncanonical inflammasome.

https://doi.org/10.1038/s41422-021-00607-5

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