Volume 32, No 2, Feb 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 2, February 2022: 115-116

RESEARCH HIGHLIGHTS

Disinhibitory feedback loops for reward and aversion

Barbara Juarez^1,2,3 , Larry S. Zweifel^1,2,3,*

¹Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
²Department of Pharmacology, University of Washington, Seattle, WA, USA
³Center for the Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA
Correspondence: Larry S. Zweifel(larryz@uw.edu)

The nucleus accumbens (NAc) region of the brain’s ventral striatum plays a central role in the regulation of appetitive and aversive motivations. A new study finds that medium spiny neurons in the NAc regulate the activity of ventral mesencephalic dopamine neurons to drive reward or aversion through direct or indirect projections.

https://doi.org/10.1038/s41422-021-00601-x

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