Volume 32, No 4, Apr 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 4, April 2022: 404-406

LETTERS TO THE EDITOR

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

Shuai Xia^1,† , Jasper Fuk-Woo Chan^2,4,† , Lijue Wang^1,† , Fanke Jiao¹ , Kenn Ka-Heng Chik⁴ , Hin Chu^2,3,4 , Qiaoshuai Lan¹ , Wei Xu¹ , Qian Wang¹ , Chao Wang⁵ , Kwok-Yung Yuen^2,3,4,* , Lu Lu^1,* , Shibo Jiang^1,*

¹Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China
²State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
³Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China
⁴Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong, China
⁵State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China
^†These authors contributed equally: Shuai Xia, Jasper Fuk-Woo Chan, Lijue Wang
Correspondence: Kwok-Yung Yuen(kyyuen@hku.hk)Lu Lu(lul@fudan.edu.cn)Shibo Jiang(shibojiang@fudan.edu.cn)

Dear Editor,

Most recently, a new SARS-CoV-2 variant of concern (VOC), Omicron (B.1.1.529), was first reported to the World Health Organization (WHO) from South Africa and then quickly spread to many countries,1,2 posing a serious threat to current vaccine prevention and antibody therapeutic strategies. Several studies have reported that the Omicron variant successfully escapes from neutralizing antibodies elicited by COVID-19 vaccines or from COVID-19 convalescent patients.3,4 Therefore, the development of potent anti-Omicron agents is urgently needed.

https://doi.org/10.1038/s41422-022-00617-x

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