Volume 32, No 4, Apr 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 4, April 2022: 401-403   |  Open Access

LETTERS TO THE EDITOR

Rapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant

Na-Na Zhang^1,2,† , Rong-Rong Zhang^1,† , Yi-Fei Zhang^1,3,† , Kai Ji^4,† , Xiao-Chuan Xiong^1,5,† , Qian-Shan Qin⁴ , Peng Gao⁴ , Xi-Shan Lu⁴ , Hang-Yu Zhou⁶ , Hai-Feng Song⁴ , Bo Ying^4,* , Cheng-Feng Qin^1,7,*

¹Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
²School of Medicine, Tsinghua University, Beijing, China
³Kunming University of Science and Technology, Kunming, Yunnan, China
⁴Suzhou Abogen Biosciences Co., Ltd., Suzhou, Jiangsu, China
⁵School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China
⁶Institute of Systems Medicine, Beijing, China
⁷Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, Beijing, China
^†These authors contributed equally: Na-Na Zhang, Rong-Rong Zhang, Yi-Fei Zhang, Kai Ji, XiaoChuan Xiong.
Correspondence: Bo Ying(bo.ying@abogenbio.com)Cheng-Feng Qin(qincf@bmi.ac.cn)

Dear Editor,

Since the declaration of public Health Emergency of International Concern (PHEIC) by the WHO, the COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to over 300 million confirmed cases with more than 5 million deaths in the past 2 years. On top of that, SARS-CoV-2 continues evolving into many variants, and many of these variants with evidence to enhance viral transmissibility, adaptiveness, infectivity, and/or to escape from host immune response are classified as variants of concerns (VOC).1 Since the outbreak of the pandemic, five VOCs, including Alpha, Beta, Gamma, Delta, and Omicron have been verified by the WHO.

https://doi.org/10.1038/s41422-022-00626-w

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