Volume 32, No 4, Apr 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 4, April 2022: 325-326

RESEARCH HIGHLIGHTS

Vein to artery: the first arteriogenesis in the mammalian embryo

Siyeon Rhee^1,* , Joseph C. Wu^1,2,3,*

¹Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
²Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
³Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
Correspondence: Siyeon Rhee(syr@stanford.edu)Joseph C. Wu(joewu@stanford.edu)

Dissecting how endothelial cells in vasculature acquire arterial characteristics is critical to understanding of arteriogenesis, but the origin of arterial endothelial cells and the arteriogenesis largely remain unknown. In a recent study from Cell Research , Hou et al. present compelling evidence of early and widespread vein-to-artery cell fate conversion in developing embryos using single-cell transcriptomic analysis and lineage tracing with a newly developed venous Cre line.

https://doi.org/10.1038/s41422-022-00629-7

FULL TEXT | PDF

Browse 778