Volume 32, No 4, Apr 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 4, April 2022: 327-328

RESEARCH HIGHLIGHTS

Revealing the secret behind Smo cholesterylation

Yuhong Han¹ , Jin Jiang^1,2,*

¹Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA
²Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA
Correspondence: Jin Jiang(jin.jiang@utsouthwestern.edu)

The GPCR family protein Smoothened (Smo) transduces Hedgehog signal across the plasma membrane. In a recent paper published in Cell Research , Hu et al. discovered that Smoothened undergoes an auto-cholesterylation process facilitated by calcium and demonstrated that covalent cholesterol attachment to Smo cysteine-rich domain is required for Hedgehog signal transduction.

https://doi.org/10.1038/s41422-022-00636-8

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