Volume 32, No 5, May 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 5, May 2022: 491-494

LETTERS TO THE EDITOR

Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209

Bin Ju^1,2,†,* , Qingbing Zheng^3,4,† , Huimin Guo^1,† , Qing Fan^1,† , Tingting Li^3,4,† , Shuo Song^1,† , , Hui Sun^3,4,† , Senlin Shen¹ , Xinrong Zhou¹ , Wenhui Xue^3,4 , Lingyan Cui^3,4 , Bing Zhou¹ , Shaowei Li^3,4,* , Ningshao Xia^3,4,* , Zheng Zhang^1,2,5,*

¹Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
²Guangdong Key laboratory for anti-infection Drug Quality Evaluation, Shenzhen, Guangdong, China
³State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China
⁴National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China
⁵Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science, Shenzhen, Guangdong, China
^†These authors contributed equally: Bin Ju, Qingbing Zheng, Huimin Guo, Qing Fan, Tingting Li, Shuo Song, Hui Sun
Correspondence: Bin Ju(jubin2013@163.com)Shaowei Li(shaowei@xmu.edu.cn)Ningshao Xia(nsxia@xmu.edu.cn)Zheng Zhang(zhangzheng1975@aliyun.com)

Dear Editor,

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants is still a pandemic raging across the world (Supplementary information, Fig. S1a, b). A new variant, Omicron, was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization (WHO), whose spike carried more than 30 mutations (Supplementary information, Fig. S1c).1,2

https://doi.org/10.1038/s41422-022-00638-6

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