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Volume 32, No 5, May 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 5, May 2022: 491-494


Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209

Bin Ju1,2,†,* , Qingbing Zheng3,4,† , Huimin Guo1,† , Qing Fan1,† , Tingting Li3,4,† , Shuo Song1,† , , Hui Sun3,4,† , Senlin Shen1 , Xinrong Zhou1 , Wenhui Xue3,4 , Lingyan Cui3,4 , Bing Zhou1 , Shaowei Li3,4,* , Ningshao Xia3,4,* , Zheng Zhang1,2,5,*

1Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital; The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China
2Guangdong Key laboratory for anti-infection Drug Quality Evaluation, Shenzhen, Guangdong, China
3State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, Fujian, China
4National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, Fujian, China
5Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science, Shenzhen, Guangdong, China
These authors contributed equally: Bin Ju, Qingbing Zheng, Huimin Guo, Qing Fan, Tingting Li, Shuo Song, Hui Sun
Correspondence: Bin Ju( Li( Xia( Zhang(

Dear Editor,

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants is still a pandemic raging across the world (Supplementary information, Fig. S1a, b). A new variant, Omicron, was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization (WHO), whose spike carried more than 30 mutations (Supplementary information, Fig. S1c).1,2


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