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Volume 32, No 5, May 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 5, May 2022: 417-418


Cuproptosis: a copper-triggered modality of mitochondrial cell death

Daolin Tang1,* , Xin Chen2 , Guido Kroemer3,4,5,*

1Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
2Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China
3Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France
4Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France
5Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
Correspondence: Daolin Tang( Kroemer(

Various heavy metals can induce regulated cell death through different subroutines. A recent study published in Science found that intracellular copper accumulation triggers the aggregation of mitochondrial lipoylated proteins and the destabilization of Fe–S cluster proteins, leading to a unique type of cell death termed cuproptosis.


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