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Submit Manuscript Volume 32, No 5, May 2022
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 32 Issue 5, May 2022: 417-418
Cuproptosis: a copper-triggered modality of mitochondrial cell death
Daolin Tang1,* , Xin Chen2 , Guido Kroemer3,4,5,*
1Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USAVarious heavy metals can induce regulated cell death through different subroutines. A recent study published in Science found that intracellular copper accumulation triggers the aggregation of mitochondrial lipoylated proteins and the destabilization of Fe–S cluster proteins, leading to a unique type of cell death termed cuproptosis.
https://doi.org/10.1038/s41422-022-00653-7