Volume 32, No 6, Jun 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 6, June 2022: 593-595   |  Open Access

LETTERS TO THE EDITOR

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

Jun Lan^1,† , Xinheng He^2,† , Yifei Ren^1,† , Ziyi Wang^1,† , Huan Zhou³ , Shilong Fan¹ , Chenyou Zhu⁴ , Dongsheng Liu⁴ , Bin Shao² , Tie-Yan Liu² , Qisheng Wang³ , Linqi Zhang^5,* , Jiwan Ge^1,* , Tong Wang^2,* , Xinquan Wang^1,*

¹The Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Collaborative Innovation Center for Biotherapy, School of Life Sciences, Tsinghua University, Beijing, China
²Microsoft Research Asia, Beijing, China
³Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China
⁴Department of Chemistry, Tsinghua University, Beijing, China
⁵Center for Global Health and Infectious Diseases, Comprehensive AIDS Research Center, and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China
^†These authors contributed equally: Jun Lan, Xinheng He, Yifei Ren, Ziyi Wang
Correspondence: Linqi Zhang(zhanglinqi@mail.tsinghua.edu.cn)Jiwan Ge(gejw@mail.tsinghua.edu.cn)Tong Wang(watong@microsoft.com)Xinquan Wang(xinquanwang@mail.tsinghua.edu.cn)

Dear Editor,

The global fight against the COVID-19 pandemic is still in great uncertainty due to the emergence of SARS-CoV-2 variants, especially the variants of concern (VOCs) with changed pathogenicity, increased transmissibility and the resistance to convalescent/vaccination sera and monoclonal neutralizing antibodies.1,2 As a newly reported VOC, the Omicron variant has caused great concern with 32 mutations in the spike glycoprotein including unprecedented 15 mutations in the receptor-binding domain (RBD), which would have significant impact on the viral infectivity and the protection effects of approved vaccines and therapeutic antibodies.3,4 A detailed description of the Omicron spike and its interactions with ACE2 receptor and neutralizing antibodies is essential for fully understanding the infection and immune escape of the Omicron variant at the molecular level.

https://doi.org/10.1038/s41422-022-00644-8

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