Volume 32, No 6, Jun 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 6, June 2022: 509-510

RESEARCH HIGHLIGHTS

Krebs and an alternative TCA cycle!

Mary T. Doan¹ , Michael A. Teitell^2,3,*

¹Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
²Department of Pathology and Laboratory Medicine, Department of Pediatrics and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
³Molecular Biology Institute, Department of Bioengineering, California NanoSystems Institute, and Broad Center for Regenerative Medicine and Stem Cell Research, University of California at Los Angeles, Los Angeles, CA, USA
Correspondence: Michael A. Teitell(mteitell@mednet.ucla.edu)

The tricarboxylic acid (TCA) cycle, first described by Krebs in the 1930s, is a center of activity for cellular metabolism, with respiratory organisms feeding specific nutrients into its cyclic sequence of catabolic biochemical reactions to produce energy and metabolites that underlie cell viability, proliferation, and function. Recently, a study by Arnold et al. in Nature identified an alternative, sub-compartmentalized version of the TCA cycle whose engagement is essential for changes in cell state.

https://doi.org/10.1038/s41422-022-00664-4

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