Volume 32, No 7, Jul 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 7, July 2022: 607-608

RESEARCH HIGHLIGHTS

Cytoskeleton grows p62 condensates for autophagy

Nobuo N. Noda^1,2,*

¹Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
²Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan
Correspondence: Nobuo N. Noda(nn@igm.hokudai.ac.jp)

p62 body, a representative selective cargo for autophagy, is known to be formed via liquid–liquid phase separation, but its spatiotemporal regulation remains largely unknown. In a recent paper published in Cell Research , Feng et al. show that branched actin filaments and Myo1D collect stochastically formed nanoscale p62 bodies and grow them into micron-scale condensate, which is prerequisite for their autophagic degradation.

https://doi.org/10.1038/s41422-022-00671-5

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