Volume 32 Issue 8, August 2022: 744-760
ORIGINAL ARTICLES
CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation
Chao Wei1,2,3,† , Lumeng Jia4,† , Xiaona Huang1,2,3,† , Jin Tan1,2,3,† , Mulan Wang1,2,3 , Jing Niu5 , Yingping Hou6 , Jun Sun1,2,3 , Pengguihang Zeng1,2,3,7 , Jia Wang1,2,3 , Li Qing1,2,3 , Lin Ma1,2,3 , Xinyi Liu1,2,3 , Xiuxiao Tang1,2,3 , Fenjie Li1,2,3,8 , Shaoshuai Jiang1,2,3 , Jingxin Liu1,2,3 , Tingting Li9 , Lili Fan10 , Yujie Sun4,11 , Juntao Gao12 , Cheng Li4,13,* , Junjun Ding1,2,3,*
1RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
2Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
3Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China
4School of Life Sciences, Peking University, Beijing, China
5School of Medicine, Tsinghua University, Beijing, China
6Peking-Tsinghua Center for Life Sciences; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
7Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
8Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China
9State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences, Beijing, China
10Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, China
11State Key Laboratory of Membrane Biology, Biomedical pioneering innovation center (BIOPIC), Peking University, Beijing, China
12MOE Key Laboratory of Bioinformatics; Bioinformatics Division, BNRist; Department of Automation; Center for Synthetic & Systems Biology, Tsinghua University, Beijing, China
13Center for Bioinformatics, Center for Statistical Science, Peking University, Beijing, China
†These authors contributed equally: Chao Wei, Lumeng Jia, Xiaona Huang, Jin Tan
Correspondence: Cheng Li(cheng_li@pku.edu.cn)Junjun Ding(dingjunj@mail.sysu.edu.cn)
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https://doi.org/10.1038/s41422-022-00676-0
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