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Volume 32, No 8, Aug 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 8, August 2022: 709-710

RESEARCH HIGHLIGHTS

A BAF-fling connection to RIPK1

Jessica M. Gullett , Thirumala-Devi Kanneganti*

Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Correspondence: Thirumala-Devi Kanneganti(Thirumala-Devi.Kanneganti@StJude.org)

RIPK1 is a multifaceted kinase with roles in diverse cellular processes, including cell death, innate immunity, and inflammatory signaling. RIPK1 can also facilitate inflammatory diseases, like amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD), independent of its cell death functions; in a recent Cell Research paper, Li et al. show that this results from RIPK1 acting as a transcriptional coregulator, forming a nuclear complex with the BAF complex through direct interactions with BRG1 and SMARCC2, mediating phosphorylation of SMARCC2, and promoting chromatin remodeling and transcription of proinflammatory genes.


https://doi.org/10.1038/s41422-022-00688-w

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