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Submit Manuscript Volume 32, No 8, Aug 2022
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 32 Issue 8, August 2022: 705-706
Towards capturing of totipotency
Cuiqing Zhong1,† , Ronghui Li2,† , Juan Carlos Izpisua Belmonte1,*
1Altos Labs, Inc., San Diego, CA, USAIn June issue of Cell Research, Xu et al. demonstrate that totipotent-like stem cells (TPS cells) can be derived directly from a 2-cell mouse embryo and extended pluripotent stem (EPS) cells by a chemical cocktail (CPEC condition). In addition, the study shows the advanced potential of TPS cells in lineage differentiation and blastocyst-like structure generation, and provides insight into mechanistic regulation of totipotency.
https://doi.org/10.1038/s41422-022-00686-y