Advanced Search

Submit Manuscript

Volume 32, No 8, Aug 2022

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 32 Issue 8, August 2022: 705-706

RESEARCH HIGHLIGHTS

Towards capturing of totipotency

Cuiqing Zhong1,† , Ronghui Li2,† , Juan Carlos Izpisua Belmonte1,*

1Altos Labs, Inc., San Diego, CA, USA
2Salk Institute for Biological Studies, La Jolla, CA, USA
These authors contributed equally: Cuiqing Zhong, Ronghui Li
Correspondence: Juan Carlos Izpisua Belmonte(jcbelmonte@altoslabs.com)

In June issue of Cell Research, Xu et al. demonstrate that totipotent-like stem cells (TPS cells) can be derived directly from a 2-cell mouse embryo and extended pluripotent stem (EPS) cells by a chemical cocktail (CPEC condition). In addition, the study shows the advanced potential of TPS cells in lineage differentiation and blastocyst-like structure generation, and provides insight into mechanistic regulation of totipotency.


https://doi.org/10.1038/s41422-022-00686-y

FULL TEXT | PDF

Browse 377